Water Mediated an Unprecedented Three-Component Reaction Leading to 5-Aryl-1,2,4-Triazolidine-3-Thiones under Catalyst-Free Conditions
A clean, cost-effective and very practical approach has been disclosed for the facile access of structurally diverse 5-aryl-1,2,4-triazolidine-3-thiones via one-pot, three-component reactions of a variety aromatic aldehydes, thiosemicarbazide and malononitrile in water without any added catalyst. Simplicity, eco-friendliness, high yield of products, rapid and robustness are the salient features of this protocol. This new chemistry is more profitable by avoiding chromatographic purifications and follows truly the principles of green chemistry with higher atom economy.
Conference Name: 11th International Conference on Science Engineering and Technology
Conference Date: 03, November 2015 - 04, November 2015
Paper ID: SET004